Prove It to Me.
Yes, we’re a little obsessed with this xylitol-fueled goodness.
So much so that we’ve scoured the ends of the earth to stay up many sleepless nights converting even the most skeptical of our friends and family.
It’s worked. They leave with smiles on their faces. For you, as for them before you, we present stuff from folks way smarter than us.
Xylitol Gum May Reduce Risk of Tooth Decay
40 month double-blind cohort study of 1,135 school children used to determine the impact of sugar-free gums on DMFS.
Patients were randomly assigned to groups and given sucrose, sorbitol, xylitol and xylitol-sorbitol sweetened gums for use under supervision of their teachers. Most significant reduction in caries risk was observed in the xylitol group.
The authors concluded that a "xylitol-based chewing gum program in basic caries prevention can be substantial."
Source: Makinen KK, Bennett CA, Hujoel PP, Isokangas PJ, Isotupa KP, Pape HR Jr, Makinen KK. Xylitol chewing gums and caries rates: a 40-month cohort study. J Dent Res 1995 Dec;74(12):1904-13.
Xylitol Toothpaste Reduced Bacteria
Six month double-blind clinical study of 155 individuals used to evaluate the effect of triclosan and xylitol on levels Mutans Streptococci.
Patients were divided into three groups and assigned dentrifice regimen: one containing fluoride, another containing fluoride and triclosan and one containing fluoride, triclosan and 10% xylitol. Toothpaste was distributed and used regularly by the three groups. The fluoride group saw almost 10% increase in levels of MS. The fluoride and triclosan group had approximately a 1% increase in MS. The fluoride, triclosan and xylitol group had more than an 18% decrease in MS.
Researchers determined that "the addition of xylitol reduces Mutans Streptococci in saliva and dental plaque."
Source: L. Jannessona, et.al, Effect of a triclosan-containing toothpaste supplemented with 10% xylitol on mutans streptococci in saliva and dental plaque. A 6-month clinical study. Caries Res. 2002 Jan-Feb;36(1):36-9.
Xylitol Gum Stopped Progress of Active Decay
24 month double blind clinical study of 510 six-year-old children used to determine the effect of xylitol on the remineralization of dentine lesions in the primary dentition.
Patients were randomly assigned to test groups and provided gum with xylitol or sorbitol. A control group did not chew gum. Participants were provided chewing gum for supervised regular use through school by their school teachers for 200 days and given instructions for use on non-school days. After the test period, researchers evaluated the remineralization of the lesions.
Researchers concluded that "high-xylitol content chewing gum usage can retard or arrest rampant dentine caries."
Makinen KK, Makinen PL, Pape HR Jr, Allen P, Bennett CA, Isokangas PJ, Isotupa KP. Stabilisation of rampant caries: polyol gums and arrest of dentine caries in two long-term cohort studies in young subjects. Int Dent J 1995 Feb;45(1 Suppl 1):93-107. PMID 7607749
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Other Studies Show Xylitol's Benefits
If you prefer to do more research on your own, below is list of additional studies about xylitol, xylitol side effects, and its potential tooth-protecting benefits:
Laitala ML, Alanen P, Isokangas P, Söderling E, Pienihäkkinen K. Long-term effects of maternal prevention on children's dental decay and need for restorative treatment. Community Dent Oral Epidemiol. 2013 Dec;41(6):534-40. doi: 10.1111/cdoe.12057. Epub 2013 Jun 20.
Mäkinen KK, Järvinen KL, Anttila CH, Luntamo LM, Vahlberg T. Topical xylitol administration by parents for the promotion of oral health in infants: a caries prevention experiment at a Finnish Public Health Centre. Int Dent J. 2013 Aug;63(4):210-24. doi: 10.1111/idj.12038. Epub 2013 Apr 15.
Campus G, Cagetti MG, Sale S, Petruzzi M, Solinas G, Strohmenger L, Lingström P. Six months of high-dose xylitol in high-risk caries subjects--a 2-year randomised, clinical trial.Clin Oral Investig. 2013 Apr;17(3):785-91. doi: 10.1007/s00784-012-0774-5. Epub 2012 Jul 13.
Shinga-Ishihara C, Nakai Y, Milgrom P, Söderling E, Tolvanen M, Murakami K. Xylitol carryover effects on salivary mutans streptococci after 13 months of chewing xylitol gum. Caries Res. 2012;46(6):519-22. doi: 10.1159/000341221. Epub 2012 Aug 10.
Milgrom P, Söderling EM, Nelson S, Chi DL, Nakai Y. Clinical evidence for polyol efficacy. Adv Dent Res. 2012 Sep;24(2):112-6. doi: 10.1177/0022034512449467.
Subramaniam P, Nandan N. Effect of xylitol, sodium fluoride and triclosan containing mouth rinse on Streptococcus mutans. Contemp Clin Dent. 2011 Oct;2(4):287-90. doi: 10.4103/0976-237X.91790.
Seki M, Karakama F, Kawato T, Tanaka H, Saeki Y, Yamashita Y. Effect of xylitol gum on the level of oral mutans streptococci of preschoolers: block-randomised trial. Int Dent J. 2011 Oct;61(5):274-80. doi: 10.1111/j.1875-595X.2011.00073.x.
Campus G, Cagetti MG, Sacco G, Solinas G, Mastroberardino S, Lingström P. Six months of daily high-dose xylitol in high-risk schoolchildren: a randomized clinical trial on plaque pH and salivary mutans streptococci. Caries Res. 2009;43(6):455-61. doi: 10.1159/000264682. Epub 2009 Dec 10.
Edelstein BL. Xylitol syrup can reduce dental caries progression in young children. J Pediatr. 2010 Jan;156(1):164. doi: 10.1016/j.jpeds.2009.09.058.
Milgrom P. Xylitol-containing oral syrup may prevent caries in children. J Am Dent Assoc. 2009 Aug;140(8):972.
Milgrom P, Ly KA, Tut OK, Mancl L, Roberts MC, Briand K, Gancio MJ. Xylitol pediatric topical oral syrup to prevent dental caries: a double-blind randomized clinical trial of efficacy. Arch Pediatr Adolesc Med. 2009 Jul;163(7):601-7. doi: 10.1001/archpediatrics.2009.77.
Splieth CH, Alkilzy M, Schmitt J, Berndt C, Welk A. Effect of xylitol and sorbitol on plaque acidogenesis. Quintessence Int. 2009 Apr;40(4):279-85.
Deshpande A, Jadad AR. The impact of polyol-containing chewing gums on dental caries: a systematic review of original randomized controlled trials and observational studies. J Am Dent Assoc. 2008 Dec;139(12):1602-14.
Milgrom P, Ly KA, Roberts MC, Rothen M, Mueller G, Yamaguchi DK. Mutans streptococci dose response to xylitol chewing gum. J Dent Res. 2006 Feb;85(2):177-81.
Holgerson PL, Sjöström I, Stecksén-Blicks C, Twetman S. Dental plaque formation and salivary mutans streptococci in schoolchildren after use of xylitol-containing chewing gum. Int J Paediatr Dent. 2007 Mar;17(2):79-85.
Aguirre-Zero O, Zero DT, Proskin HM. Evaluation of the dental plaque pH recovery effect of a xylitol lozenge on patients with fixed orthodontic appliances. Angle Orthod. 2004 Apr;74(2):240-4.
Isokangas P, Söderling E, Pienihäkkinen K, Alanen P. Occurrence of dental decay in children after maternal consumption of xylitol chewing gum, a follow-up from 0 to 5 years of age. J Dent Res. 2000 Nov;79(11):1885-9.
Hildebrandt GH, Sparks BS. Maintaining mutans streptococci suppression with xylitol chewing gum. J Am Dent Assoc. 2000 Jul;131(7):909-16.
Mäkinen KK, Hujoel PP, Bennett CA, Isokangas P, Isotupa K, Pape HR Jr, Mäkinen PL. A descriptive report of the effects of a 16-month xylitol chewing-gum programme subsequent to a 40-month sucrose gum programme. Caries Res. 1998;32(2):107-12.
Mäkinen KK, Hujoel PP, Bennett CA, Isotupa KP, Mäkinen PL, Allen P. Polyol chewing gums and caries rates in primary dentition: a 24-month cohort study. Caries Res. 1996;30(6):408-17.